Volume 3, Issue 4
Evaluation of antioxidant and cytotoxic activity of methanolic extract of Mimosa pudica leaves
Author: Kamanashis Das, Md. Yasin, Nasir Uddin Mahbub, Md. Shahidul Islam, Nayma Mahbuba
Abstract: In this study methanolic extract of Mimosa pudica (Mimosaceae) leaves was investigated to evaluate its antioxidant and toxic properties. Antioxidant activity was evaluated using total phenol content, total antioxidant capacity, total flavonoid contents and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays. The methanolic crude extract showed moderate antioxidant activity such as total flavonoid content was found to be 63.8 mg QE/g and total phenol content was 42.9 mg GAE/g. The total antioxidant capacity was expressed as ascorbic acid equivalents (AAE) and for leaf it was 5.038 mg/g AAE. DPPH scavenging activity was measured by comparing with ascorbic acid. Both leaf and ascorbic acid IC50 values were 126.71 and 20.13µg/ml, respectively. On the other hand, the cytotoxic activity of methanolic extract of leaf was evaluated using brine shrimp lethality bioassay. LC50 value of the methanolic leaf extract of Mimosa pudica was found to be 282.3495µg/ml and its showed lethality in a dose reliant conduct. In brine shrimp lethality bioassay, Mimosa pudica leaf showed significant source of anticancer compounds.
Fig: Graphical representation of cytotoxic activity of crude extracts on shrimp nauplii of Mimosa pudica leaves by brine Shrimp lethality bioassay method.
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