Volume 3, Issue 3


Evaluation of nootropic activity of smrithi: a polyherbal formulation


Author: Jyothi Vadthya , Satyavati. D , Pradeep Kumar .C , Ch. Maheshwara Reddy

Abstract: In the present study ‘Smrithi’ selected for evaluation of its nootropic activity in different experimental animal models like Scopolamine induced cognitive deficits in mice on Elevated plus maze (EPM) and Morris water maze (MWM) tasks. Smrithi was administered for seven days at the dose of 100 and 200 mg/kg body weight, scopolamine (0.3 mg/kg) was used to induce amnesia, piracetam (50 mg/kg) and Mentat (1and 2 ml/kg) served as reference standards. Smrithi treated animals significantly (p<0.01) reduce the Transfer latency on Elevated plus maze and Escape latency in Morris water maze when compared with that of standard nootropic Piracetam, standard polyherbal formulation Mentat and a control group of animals. The probable mechanism of action of Smrithi might be due to its ability to elevate Acetylcholine levels by significant reduction of Acetylcholinesterase enzyme activity in the brain and ultimately improved memory. In the light of above, it may be worthwhile to explore the potential of this formulation in the management of Alzheimer’s patients.

Effect of test drugs on spatial memory in elevated plus-maze

fig: Effect of test drugs on spatial memory in elevated plus-maze *p<0.05 and **p<0.01 control Vs treated groups using one way ANOVA followed by Dunnett’s test

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