Volume 3, Issue 1


Evaluation of hepatoprotective activity of
Zizizphus nummularia fruits on carbon tetrachloride induced hepatotoxicity in rats


Author: G.Deepika Sri Prashanthi*, K.Upendar, N.Siva Subramanian, Pradeep H.A,  P.Renuka Tejasvi, K.Seshachary Anusha

Abstract: During past several years, there has been growing interest among the usage of various medicinal plants from traditional system of ailments. The objective of this study was to evaluate the hepatoprotective activity from methanol extract derived from the Ziziphus nummularia Fruits. Oral administration of the extract (100 and 200 mg/kg body weight) lead to a significant reduction in ALAT, ASAT and ALP levels in CCl4 induced hepatotoxicity in rats. Phytochemical screening also revealed that the extract contains Alkaloids, Phenolic compounds, Flavonoides and Tannins. The presence of poly phenols and flavonoids support its antioxidant potential. The drug, thus, is rich source of various antioxidant chemicals producing favorable action in protecting against various free radicals and show hepatoprotective activity.

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