Volume 3, Issue 1


A comparative effectiveness of different antibiotics in management of mild community-acquired pneumonia


Author: Ya. O. Dziublyk 1
1. National institute of phthisiology and pulmonology, named after F. G. Yanovskiy NAMS of Ukraine, Kyiv, Ukraine.

Abstract: Current guidelines for the management of community-acquired pneumonia recommend using different antimicrobial drugs. The purpose of this open randomized parallel group study was to assess efficacy and cost-efficiency of three most commonly used oral antibiotics in patients with mild community-acquired pneumonia. 45 out-patients were randomly distributed into 3 groups to receive oral treatment with either amoxicillin 500 mg thrice daily, or azithromycin 500 mg once daily or levofloxacin 500 mg once daily. In terms of treatment outcomes the efficacy of study drugs was 93,3% (amoxicillin group), 86,7% (azithromycin group) and 100% (levofloxacin group) (р>0,05). The results of pharmacoeconomic analysis revealed a lower cost of treatment with amoxicillin and azithromycin versus levofloxacin.


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