Volume 2, Issue 8


Effect of aqueous extract of Ageratum conyzoides leaves on the glycaemia of rabbits


Author: Doh Koffi Stéphane*, N'guessan Koffi and Aké Claude Bernard
Université Félix Houphouët-Boigny (Côte-d’Ivoire); U.F.R. Biosciences ; Laboratoire de Botanique ; 22 BP 582 Abidjan 22 (Côte-d’Ivoire).

Abstract: Diabetes is an alarming affection which affects 5% of the population in Côte-d’Ivoire. In the search of means of fighting, we evaluated, experimentally, the effect of Ageratum conyzoides leaves used by traditional healers to treat diabetes. The rabbits used received orally a solution of glucose (4 g/l) to cause hyperglycaemia. As treatment, the hyperglycaemic rabbits were given, glibenclamide (0.25 mg/ml) and herbal medicine to drink. The rabbits deprived of food overnight had basic glycaemia of 1.02 g/l. The untreated rabbits’ glycaemia increased and reached 1.20 g/l. The glibenclamide lowers blood sugar at 0.7 g/l. The others hyperglycaemic rabbits received different graded doses of the herbal medicine.  At 2 mg/ml, phytomedicine does not induce hypoglycaemic effect. At 20 mg/ml, its hypoglycaemic effect is light. At 200 mg/ml, the herbal medicine exerts a significant glucose-lowering hypoglycaemic effect that is comparable to those of glibenclamide, appears like an antidiabetic.

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