Volume 2, Issue 8


Pathomorphosis of Cervical Cancer Stage IIb With the Applying of Preoperative Therapy


Author: Anna Ye. Kryzhanivska 1, Elvira O. Kindrativ 2, Ivan O. Mikhailyuk 2
1. Department of Oncology Ivano-Frankivsk National Medical University Ivano-Frankivsk, Ukraine
2. Department of PathomorphologyIvano-Frankivsk National Medical University Ivano-Frankivsk, Ukraine.

Abstract: The article contains the results of study treatment the pathomorphosis squamous cell cervical cancer stage IIb using preoperative therapy. The study included 127 patients with cervical cancer stage IIB , of which 53 received preoperative course of external beam radiotherapy to 2 Gray to a total dose of 30 Gray with potentiation of cisplatin 40 mg/m2 weekly and 74 who applied neoadjuvant systemic chemotherapy according to the scheme FR (cisplatin 100 mg/m2, 5-fluorouracil 1000 mg/m2 from 1st to 4th day) 2-3 courses every 3 weeks, surgical intervention in the volume of panhisterectomy type III. The degree of therapeutic pathomorphosis of parenchymatous-stromal components was evaluated on a scale according to G.A. Lavnikova (1976).  Methods of preoperative therapy that we used, led to the development of pronounced therapeutic pathomorphosis, especially in patients who received radiation therapy. Morphological and morphometric study of surgical specimens showed that therapeutic pathomorphosis after application of preoperative chemotherapy allows to achieve tumor devitalization. Consequently, the use of preoperative chemotherapy and radiation therapy are objective conditions for the realization of maximum possible effect of anti blastomic action, that corresponding the operating principles of ablation procedures.

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