Volume 2, Issue 7


Influence of Liraglutide alone and in combination with Glimepiride on hepatic function in obese-diabetic rabbits


Author: Dharmaraj. B,1 R. K. Srivastava,1 Rajeev sen2, Veena Ghalaut3 and Sushila Godara1
1. Department Of Pharmacology, Pt. B. D. Sharma PGIMS, Rohtak, India.
2. Department of Pathology, Pt. B. D. Sharma PGIMS, Rohtak, India.
3. Department of Biochemistry,Pt. B. D. Sharma PGIMS, Rohtak,

Abstract: The study was done to find out the effect of liraglutide alone and in combination with glimepiride on hepatic function in obese diabetic rabbits. Obesity was produced with HFD (High fat diet) given for 10 weeks and diabetes was induced with dithizone (5 mg/kg i.p.). All the obese-diabetic rabbits showed elevated levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), BGLs (Blood glucose levels) and increased fatty infiltration of liver. Liraglutide (7μg/kg) s.c. decreased the elevated levels of AST, ALT, BGLs and reduced fatty infiltration of liver in obese-diabetic rabbits. However, combined effect of liraglutide and glimepiride (2 mg/kg orally) failed to show any improvement of hepatic dysfunction rather worsened the impairment. It is therefore concluded that Liraglutide alone and not in combination with glimepiride is effective in improving the hepatic dysfunction of obese-diabetic rabbits.

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