Volume 2, Issue 7


Assessment of Phytochemical, Analgesic and Antioxidant Profile of Melia azedarach L. [Leaves] (Family-Meliaceae)


Author: MD. Shafayat Hossain 1*, Abu Saed1, Utpal Kumar Karmakar 1, MD. Anwar Hossain1
1. Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh.

Abstract: This project is designed to evaluate the potential analgesic and antioxidant activity of Melia azedarach L. to judge the traditional uses of this medicinal plant. The ethanolic extract of the dried leaves of Melia azedarach L. (Family: Meliaceae) was assessed for its possible analgesic and antioxidant activity. Photochemical screening of the ethanolic extract revealed the presence of alkaloids, glycosides, tannins, Saponins and Flavonoids. In acetic acid induced writhing in mice, the ethanolic extract (250 and 500 mg/kg) exhibit significant (P<0.001) inhibition of writhing reflex 45.45% and 67.05% respectively compared to standard Diclofenac Sodium 76.14% (P<0.001) at a dose 25mg/kg body weight. The ethanolic extract showed antioxidant activity. In qualitative antioxidant assay using 1, 1-diphenyl-2-picryl hydrazyl the extract showed free radical scavenging properties. In the quantitative assay, extract displayed free radical scavenging activity in the assay (IC50~95µg/mL) which is comparable to that of ascorbic acid (IC50 ~15µg/mL), a well-known standard antioxidant.

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