Volume 2, Issue 6


Structural Changes of Endocrine Juxtaglomerular Complex of the Kidney Caused by the Combined Effect of the Man–Made Environmental Factors


Author: Lyubov Shvets*
Department of Medical Biology and Medical Genetics, SHEE “Ivano-Frankivsk National Medical University”, Ivano-Frankivsk, Ukraine

Abstract: The analysis of morphometric indices and ultrastructural characteristics of the components of the renal endocrine juxtaglomerular complex (juxtaglomerular cells and macula densa cells) in 80 rats and mice kept in different parts of the Carpathians for two and four months has been done. The trend to increasing diameters and volumes of cells and cytoplasm while reducing nuclear-cytoplasmic index of juxtaglomerular cells of all types of granularity and macula densa cells of animals, kept in bad ecological regions, was mentioned: chemically polluted towns (Kalush and Burshtyn), increased radiological control zone – the village of Stetseva (Snyatyn region). The most significant changes in morphometric indices and activation of biosynthetic processes in cells (granularity of type II) were found. Cells (granularity of type III) containing a large number of secretory granules and macula densa cells were found to be the least sensitive sells to the anthropogenic environmental factors. The dependence of morphometric indices and ultrastructural characteristics of endocrine juxtaglomerular cells and macula densa sells of the animals’ kidneys (control group) on the degree of pollution and the duration of the number of anthropogenic factors (different regions of Carpathians) was proved. The data may be considered as the result of adaptive changes of renal endocrine juxtaglomerular complex by man–made pollution effect.

Download Full Article: Click Here


Support Us

If you are interested in supporting our work and would like to contribute, you are welcome to mail me at jpbr.anil@gmail.com or at info@thepharmajournal.com it will be a great help and will surely be appreciated.