Volume 2, Issue 5


Synthesis and Characterisation of 3-Acetylindole Derivatives and Evaluation of Their Anti-Inflammatory and Anti-Microbial Activity


Author: Loveleen Verma *, Dr. Sharad Wakode
Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), Sector-3, Pushp Vihar, New Delhi-110017, India.

Abstract: A series of 3-Acetylindole derivatives were synthesised by a three step process by reacting 3-acetylindole and aromatic aldehydes in the first step. The purity and structure confirmation of the synthesised compounds were done by TLC and 1H-NMR. The compounds were evaluated for anti-microbial and anti-inflammatory activity. The test compound LV-5 showed highest anti-inflammatory activity and the test compounds LV-5, LV-6 and LV-8 showed highest anti-microbial activity.

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