Volume 2, Issue 5


Role of Calcitonin Gene-Related Peptide (CGRP) in Migraine: A Review


Author: Vandana *, Kumar S.L. Hari , Chand Hukkam and Navis Silvia
Deptt. of Pharmacology, Rayat and Bahra Institute of Pharmacy, Sahauran, Mohali (Punjab), India.

Abstract: The neuropeptide calcitonin gene-related peptide (CGRP) has long been postulated to play an integral role in the pathophysiology of migraine. While clinical findings are consistent with such a role, the specific pathogenic mechanisms of CGRP in migraine have remained speculative until recently. Through advances in molecular neuroscience, the pathogenic mechanisms of CGRP in migraine have begun to be elucidated. This paper discusses the hypothesized role of CGRP in migraine and reviews recent findings on the molecular mechanisms of this neuropeptide in migraine pathophysiology.

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