Volume 2, Issue 5


Characteristic of Immunological Changes in Odontogenic Cysts


Author: Ulyana Lytvynets-Holutyak *
Department of Dentistry Faculty of Continuing Education Ivano-Frankivsk National Medical University 76000, Ivano-Frankivsk, Ukraine

Abstract: The study involved 67 patients with odontogenic cysts (OC) aged 18 to 45 years, who were divided into groups: Group 1 (n = 67) patients with OC aged 18 to 45 years, group 2 - control group, consisted of 20 healthy persons of similar age. We studied the characteristics of immune status and immunoreactivity in patients with odontogenic cysts. Condition of cellular and humoral immunity was assessed by using the methods of direct rosette developing with erythrocytes coated with monoclonal antibodies to CD3 +, CD4 +, CD8 +, CD22 +, CD4/CD8 indicators ofimmunoregulatory index and phagocytic immunity. State of nonspecific resistance was studied by determining the phagocytic activity of neutrophils and their oxygen dependent metabolism in NBT test. The concentration of cytokines (IL-6 and IL-4) in serum was determined by ELISA. During the study we found that in patients with (OC) developed significant changes in the structure of the immune response at the cellular as well as at the humoral level that makes it necessary to develop new individualized preventive measures along with existing therapies OC.

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