Volume 2, Issue 5


Relationship Between Hemodynamic and Cytokines Disorders Depending of Endogenous Insulin Levels in Hypertensives with Heart Failure


Author: Oleg M. Sheremeta*
Department of internal medicine of stomatological faculty Ivano-Frankivsk National Medical University Ivano-Frankivsk, 76000, Ukraine

Abstract: The study of relationship between blood pressure (BP) disorders and cytokines activation in 114 hypertensives with HF class II-III NYHA (45 male, 69 female), aged 59±12 years, and different endogenous insulin (EI) levels was performed. We revealed the increasing of ABPM parameters depending to plasma EI levels and severe class of HF. Increasing of proinflamatory TNF-α in hypertensives with normal EI levels is more typically for HF class III NYHA. Anti-inflammatory cytokine IL-10 levels are increased in the early HF stages. The patients with 2hr postloading hyperinsulinemia are characterized by a significant increasing of proinflammatory and anti-inflammatory cytokines activity depending to HF progression compared with patients with normal EI levels. The highest plasma TNF-α, IL-6 and IL-10 levels and their ratios were revealed in patient with fasting hyperinsulinemia and HF class III.

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