Volume 2, Issue 4


Synthesis, characterization and Screening of 1,2,4 Triazole Derivative Compounds for Its Antimicrobial Activity


Author: Sushma Dev*, Dr Ramesh Bodla

Department of Pharmaceutical chemistry, Delhi Institute of Pharmaceutical Science and Research (DIPSAR), Sector-3, Pushp Vihar, New Delhi-110017, India.

Abstract: A series of 3-benzoylsulfanyl derivatives of 4-methyl-1,2,4-triazole were synthesized by acylation of starting triazole-3-thiol with appropriately substituted benzoyl halide. All members of the set were evaluated for in vitro antimicobacterial activity against Psuedomonas aerogenosa, Escherichia coli, Bacillus subtilis, Bacillus pumitis and antifungal acivity against A. niger, C. albicans. The activities were expressed as the minimum inhibitory concentration. The compound exhibited only a moderate or slight antimycobacterial activity. The structures of the newly synthesized compounds were characterized by IR, 1H NMR and elemental analysis.

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