Volume 2, Issue 4
Diagnostic Significance of Cytogenetic Markers of Asthma in Children
Author: Ludmyla Lytvynets
Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ivano-Frankivsk, st. J. Frank, 25A, Apt. 48, 76018. Ukraine.
Abstract: Research of cytogenetic features of the kariotype in children with bronchial asthma was conducted by studying specimens of prometaphase chromosomes of peripheral blood lymphocytes. We analyzed associations of acrocentral number of chromosomes, karyotype features. The study involved 82 children aged 6 to 18 years with asthma of varying degrees of its control over the outcome of asthma control test. Children with uncontrolled asthma received significantly higher rate of chromosome acrocentral associations 13-15 (DD), 21-22 (GG) and 13-15 - 21-22 (DG). In patients with asthma we observed a lower mitotic activity compared with that in healthy ones (PN <0,05), and with a lower degree of controllability it decreased.
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