Volume 2, Issue 3
Formulation Development And Evalution Of Immediate Release Tablet Of Anti Hypertensive Drug Olmesartan Medoxomile.
Author: M.M Gupta, Mayur mahida*
Jaipur college of pharmacy, jaipur, rajasthan, India.
Abstract: Olmesartan medoxomile blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding to the AT1 angiotensin II receptor. ACE inhibitor is used in treatment of hypertension. Olmesartan medoxomile tablet have been prepared by wet granulation method and also by direct compression. Effect of various fillers and disintegrants were also explored. Microcrystalline cellulose, lactose monohydrate, were used in wet granulation. In order to obtain acceptable product several trials were conducted and ten different formulations were prepared. Various pharmacopoeial evaluations of the formulations were conducted including weight variation, hardness, disintegrationtime, friability and in-vitro dissolution. Final selection of formulation was done based on pharmaceutical equivalence of development formulation to that of marketed one.
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