Volume 2, Issue 3


A Review on Design and Development of Thermosensitive Occular in Situ Gel Ophthalmic Formulation


Authors: Ganapaneni Krishna Chaitanya*, Dasari Nagaraju, Mutchu Giriprasad, G.V.Siva Sankara Kumar, Sreekanth Nama, B.Brahmaiah

Department of Pharmaceutics, Priyadarshini Institute of Pharmaceutical Education & Research(PIPER), 5th Mile, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur-522017, Andhra Pradesh, India.

Abstract: The design of the ophthalmic delivery system that enhances the bioavailability and to increase the residence time with improved mechanical properties and mucoadhesive properties has to be prepared in order to overcome the problems associated with the conventional ophthalmic solutions i.e., these conventional formulations eliminate rapidly after administration and cannot provide and maintain an adequate concentration of the drug in the pre corneal area and In order to avoid the rapid dilution, formulations with an increased viscosity have been evaluated. Among them, the thermo sensitive in situ gel-forming formulations, which undergo phase transition from liquid to semisolid gel upon exposure to physiological environments, seem to be a promising tool. Thermo sensitive in situ gelling and mucoadhesive ophthalmic drug delivery system is designed by employing poloxamer 407 as thermo gelling agent under physiological conditions in the ocular environment it under gones sol to gel phase transistion. The mucoadhesive material includes carbopol, chitosan, hydroxypropylcellulose (HPC), polycarbophil, polyvinylpyrrolidone (PVP) in various ratios inoder to obtain optimum muchoadhesive which plays a vital role in enhancing bioavailability.

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