Volume 2, Issue 2


Preparation and Characterization of Mucoadhesive Microspheres Containing Clopidogrel


Authors: Jimidi.Bhaskar*, Malothu.Jagadish Naik
Department of Biotechnology Acharya Nagarjuna University, Nagarjuna nagar, Guntur, Andhra pradesh, India.

Abstract: Clopidogrel bisulphate has been the most widely used as antithrombotic. Clopidogrel has greater solubility in acidic pH and it is absorbed through gastrointestinal region. The aim of the present research work was to develop the mucoadhesive micro-spheres containing clopidogrel. The micro-spheres were prepared by ionotrophic gelation method. The microcapsules were prepared with HPMC K4M, Xanthan gum and pectin along with sodium alginate. The prepared micro-spheres were characterized for various physicochemical properties such as , particle size distribution, entrapment efficiency, in vitro dissolution, in vivo radiographic study, DSC, FTIR and SEM study. In vitro drug release study showed that the drug release was extended up to 14 hours and the drug release was mainly depend on the polymer ratio and polymer concentration. In vivo radiographic study revealed that the prepared micro-spheres retained in the stomach for more than 6 hours. DSC and FTIR study showed no drug polymer interaction. SEM study showed the spherical and porous nature of the prepared micro-spheres.

Download Full Article: Click Here


Support Us

If you are interested in supporting our work and would like to contribute, you are welcome to mail me at jpbr.anil@gmail.com or at info@thepharmajournal.com it will be a great help and will surely be appreciated.