Volume 2, Issue 11


Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Caused by Viruses: The need of Combined Anti-Infective Chemotherapy


Author: Ya. О. Dziublyk

Abstract: The aim of the study was to evaluate the effectiveness of combined antibacterial and anti-viral therapy of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), caused by viruses.
Materials and Methods: 56 patients with AECOPD, triggered by acute respiratory viral infection (ARI) were enrolled. All patients were administered amoxicillin/clavulanate 1000 mg twice daily plus vitaglutam 90 mg once daily (1st group) or amoxicillin/clavulanate 1000 mg twice daily (2nd group). All patients were examined using physical and laboratory tests. Biological samples of all patients were also tested in order to identify viral and bacterial pathogens.
Results: In patients of 1st group we observed shorter use of antibiotic, lower rate of infectious complications and faster clinical and laboratory recovery. The data of pharmacoeconomical analysis indicated that the cost of antimicrobial therapy was lower in the 1st group as well.

Conclusion: A combined anti-infective therapy, enhanced by anti-viral medication vitaglutam, could significantly improve the outcomes of treatment of patients with AECOPD, caused by viruses.

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