Volume 2, Issue 1


The Methods of Correction of Endothelial Dysfunction and Systemic Inflammation in Patients with Chronic Pyelonephritis and Hypertension


Author: Oksana Luchko *, Miroslavа Misyachenko
Department of Internal Medicine № 2, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine.

Abstract: The aim of research was to improve treatment of endothelial dysfunction and systemic inflammation in patients with chronic pyelonephritis (CPN) and hypertension (HPT) by using Meldonium and Canephron N. To do this, we examined 105 patients with CPN and HPT, among whom were 64 (60.95%) men and 41 (39.05%) female, aged from 35 to 74 years (average 56.044.15 years). In these same patients revealed signs of endothelial dysfunction and systemic inflammation. Application to the basic therapy of CPN and HPT Meldonium and Canephron N improve the elastic properties of elastic arteries, particularly reduce endothelin-1, cardio-ankle vascular index, pulse wave velocity, aortic stiffness index, thickness intima - media complex and increase endothelium dependent vasodilatation and endothelium independent vasodilatation. Meldonium and Canephron N potentiates the decrease in the intensity of systemic inflammation by positive dynamics of C-reactive protein, soluble intercellular adhesion molecule-1, interleukin-1β, interleukin-6 and tumor necrosis factor-ɑ. Thus, the combined use of Meldonium and Canephron N is feasible, effective and safe for prolonged use.

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