Volume 1, Issue 9

Formulation And Characterization of Clarithromycin Loaded Mucoadhesive Microspheres by Emulsification Solvent Evaporation for Anti-Helicobactor pylori Therapy

Malik K.

Abstract: Helicobacter pylori (H. pylori) infection has a strong association with chronic active gastritis and duodenal ulcer (DU). H. pylori infection can be detected in 90% of patients with DU and 70% of those with gastric ulcers. The most successful and universal treatment is triple therapy, three d rugs twice a day for 1 week (proton pump inhibitor [PPI], amoxicillin and clarithromycin). However, some other reports and clinical trials indicate that the therapies cannot bring out complete eradication of H. pylori and suggest that the therapeutic effect needs more investigation. One of the reason for incomplete eradication is probably that the residence time of antimicrobial agents in the stomach is so short that effective antimicrobial concentrations cannot be achieved in the gastric mucous layer or epithelial cell surfaces where H. pylori exists. One way to improve the efficacy in eradicating the infection is to deliver the antibiotic locally in the stomach. Considering above issue, we have prepared clarithromycin loaded microspheres for anti – H. pylori Therapy. The microspheres were prepared by the w/o emulsification solvent evaporation method using mucoadhesive polymers sod. CMC and a release controlling polymer sod. alginate. The shape and surface morphology of prepared microspheres were characterized by optical  microscopy . In vitro drug release studies were performed and drug release evaluated.

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