Volume 1, Issue 7

A Comprehensive Review of  Pulsatile Drug Delivery System


Authors: Grover Chandani*, Bhatt Ganesh, Kothiyal Preeti

Abstract: Novel Oral Drug Delivery technologies have emerged and expanded into  different drug delivery system with different drug release mechanisms. Sophisticated instrumentation,modern mathematical models and computation power have advanced the concept of drug delivery from a simple pill to a programmable time controlled smart system Pulsatile drug delivery system (PDDS) is  the most interesting  time - and site-specific system as per the patho-physiological need of the disease. This system is receiving increasing interest for the development of drugs for which conventional controlled drug release system with continuous  release  are not ideal. These drugs are having high first –pass effect or special chronopharmological needs. Pulsatile drug release  profile is  characterized by time period of  no release  (lag time) followed by a rapid  and complete drug release. Diseases requiring PDDS includes asthma, peptic ulcers, cardiovascular diseases, arthritis, attention deficit syndrome in children and  hypercholesterolemia. PDDS can be classified into:  a) time controlled systems wherein the release of drug being controlled by the system itself  (b) stimuli induced PDDS in which release is controlled by the stimuli  like the pH or enzymes present in the intestinal tract or enzyme present in the drug delivery system (c) Externally  regulated system in which the drug  is handled and  controlled by external stimuli  like  magnetism, irradiation, electric effect and ultrasound. Various systems  like capsular systems, osmotic systems based  on the use of  erodible polymer or soluble coating, use of  ruputurable  membranes.

Keyword: Pulsatile Release,Chronotherapeutics, Time Controlled System, pH Targeted Release.

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