Volume 1, Issue 12


In Vitro Nitric Oxide Scavenging Activity Of Methanol Extracts Of Three Bangladeshi Medicinal Plants


Authors: Rozina Parul*, Pijush Saha and Sukalayan Kumar Kundu
Department of Pharmacy, Gono Bishwabidyalay, Savar, Dhaka – 1344, Bangladesh.

Abstract: The methanol extracts of three medicinal plants named Phyllunthus freternus, Triumfetta rhomboidae and Casuarina littorea were examined for their possible regulatory effect on nitric oxide (NO) levels using sodium nitroprusside as a NO donor in vitro. Most of the extracts tested demonstrated direct scavenging of NO and exihibited significant activity and the potency of scavenging activity was in the following order: Phyllunthus freternus > Leaves of Triumfetta rhomboidaeCasuarina littorea > barks of Triumfetta rhomboidae  > roots of Triumfetta rhomboidae. All the evaluated extracts exhibited a dose dependent NO scavenging activity. The methanolic extracts of Phyllunthus freternus showed the greatest NO scavenging effect of 60.80% at 200 µg/ml with IC50 values 48.27 µg/ml as compared to the positive control ascorbic acid where 96.27% scavenging was observed at similar concentration with IC50 value of 5.47 µg/ml. The maximum NO scavenging of Leaves of Triumfetta rhomboidae, barks of Triumfetta rhomboidae, roots of Triumfetta rhomboidae and Casuarina littorea were 53.94%, 50.43%, 33.23% and 54.02% with  IC50 values 97.81 µg/ml, 196.89 µg/ml,  > 200 µg/ml and  168.17  µg/ml respectively. The present results suggest that these plants might be potent and novel therapeutic agents for scavenging of NO and the regulation of pathological conditions caused by excessive generation of NO and its oxidation product.

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