Volume 1, Issue 11


Synthesis, Characterization And Evaluation For Anticonvulsant Activity Of Acetylnaphthalene and Substituted Acetylenaphthalene Derivative Of Heterocyclic Compounds


Authors: Sunil kumar, D. P. Pathak
Research Scholar, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), New Delhi, India

Abstract: A series of acetylnaphthalene and substituted acetylnaphtahlene have been prepared by mannich reaction with four different  secondary amine compounds and formandehyde. In this reaction Acetyl gruoup of acetyl naphthalene and substituted acetylnaphthalene have been used as hydrogen active compound. The structures of new compounds have been confirmed by spectral data. The novel compounds were tested for anticonvulsant activity using pentylenetetrazole (scPTZ) test. Among the tested  some acetylnaphthalene and substituted acetyl naphthalene derivatives of heterocyclic compounds were show significant anticonvulsant activity.

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