Abstract:A study was conducted to examination of the clinical signs and gross lesions of lead acetate, tetramethyl thiuram disulfide, individual and its combination induced toxic effects in broilers. Hundred day old broiler chicks divided into four groups, in each group has 25chicks. The control group fed with basal diet, lead acetate @ 300 ppm per day, tetramethyl thiuram disulfide @ 60 ppm per day and its combination of lead acetate and tetramethyl thiuram disulfide with same dose. The clinical signs observed as greenish diarrhoea, torticollis, prostration, weight loss, lethargy, hock sitting position. The gross pathology was observed moderate congestion of liver and kidneys, bowing and moderate bending, gradual shortening of tibial bones were noticed.