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Vol. 12, Special Issue 7 (2023)

BMP4 gene expression in native goat breeds in Kerala

Author(s):
Charlotte Coretta Rodricks, KA Bindu, S Pramod, RS Abhilash, PV Tresamol and TV Aravindakshan
Abstract:
Bone morphogenetic proteins (BMPs) are multifunctional cytokines belonging to the transforming growth factor family and play a vital role in early embryonic development, tissue homeostasis and inhibition of progesterone synthesis. It was also reported to have an effect on skeletal development and adipogenesis regulation. The present study was undertaken to compare the expression of the BMP4 gene in the ovary and the uterus of Malabari and Attappady Black goats. Samples were collected from the uterus and the ovary from the abattoir and the RNA was isolated. The isolated RNA was converted to cDNA and was used for real-time PCR analysis with GAPDH as reference gene. The ovary of Attapady Black goat breed had a 0.26-fold lower expression of BMP4 than that in the ovary of the Malabari goat breed (p<0.05). Statistical analysis revealed a 0.13-fold decrease of BMP4 expression in the ovary compared to the uterus (p<0.05). A significant difference was observed in the expression of BMP4 gene between tissue samples (Uterus and ovary) as well as between the two breeds (p<0.05).
Pages: 1430-1435  |  186 Views  83 Downloads
How to cite this article:
Charlotte Coretta Rodricks, KA Bindu, S Pramod, RS Abhilash, PV Tresamol and TV Aravindakshan. BMP4 gene expression in native goat breeds in Kerala. The Pharma Innovation Journal. 2023; 12(7S): 1430-1435.

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