Vol. 12, Special Issue 12 (2023)

Author(s):
Mrinalini Saran, Manoj Kumar Kalwaniya, SK Kashyap, Manisha Doot, Lokendra and Mayank Agrwal

Abstract:
The benefits of milk as a food source for nutrients have long been recognized. Most milk proteins (80% and 10%, respectively) are made of casein and whey. One of the essential milk proteins in cows, -casein (-CN), is encoded by a collection of highly polymorphic genes, leading to the production of 12 distinct protein variants. A1 and A2 are among their most prevalent variations. Comparing Bos taurus and Bos indicus, the latter has a larger percentage of the A2 type -CN. The synthesis of -casomorphin-7 (BCM-7) during gastrointestinal proteolytic digestion is a risk for milk carrying A1 or A1/A2 -CN variations, which has been connected to a number of health problems in humans. The purpose of the present study was to examine the incidence of -CN mutations among Tharparkar and Kankrej.