Vol. 11, Special Issue 8 (2022)

Author(s):
Vani A, Rohit Singh, Sourabh Babu, Chandra Pratap, Mukesh Gangwar and Manish Arya

Abstract:
“Ichthyosis” refers to several cutaneous keratinization disorders which affect both man and animals and mostly have a genetic origin. In animals, this disease has been reported in cattle, swine, dogs, chicken, mice, llamas, kudu, sheep and goat. It poses economic and animal welfare issues. Two forms of the disease are described in cattle: ichthyosis fetalis (severe and fatal form) and ichthyosis congenita (mild form). Earlier, the diagnosis was mostly based on clinical examination findings and histopathology. At present genetic heterogeneity of inherited ichthyosiform disorders can be analyzed using whole-genome sequencing (WGS)-based precision diagnostics. In humans ichthyotic disorders are associated with variants in more than 50 genes with varied functions. In animals, specific allelic variants have been identified only in a few populations as of now mainly in cattle. This review presents the genetic basis of ichthyotic disorders in animals.