Vol. 11, Special Issue 4 (2022)

Author(s):
Richa Mishra, Asit Kumar and BP Tripathi

Abstract:
Cyanobacteria produce variety of secondary metabolites that are not essential for primary metabolism of organisms and include compounds that can operate as allelo-chemicals, antibiotics, hormones, and toxins. Secondary metabolites of so many strains of cyanobacteria have been studied extensively and their antimicrobial properties such as antibacterial, antifungal, antialgal, & anticyanobacterial have been observed. To focus on the antibacterial behavior of the exogenous cyanotoxins, in-vitro study was carried out. Cyanobacterial strains, Anabaena variabilis, Microcystis robusta, and Oscillatoria splendida has been isolated from local ponds. Actions of methanol extract of isolated Cyanobacterial strains against clinically important standard pathogenic bacterial strains i.e. E. coli (ATCC-25922) and Staphylococcus aureus-(ATCC 25923) were investigated. Zone of inhibition was (ZOI) formed by all the antibiotics and extracts, were measured. The result showed that there is gradual suppression of growth exhibited by the pathogen with increasing concentration of extract over control. The outcome indicated that all the Mirocystis robusta and Oscillatoria splendida. posses a potential broad spectrum of antibacterial activity then Anabaena variabilis and that may lead in the development of new pharmaceuticals that address unmet therapeutic needs.