Vol. 11, Special Issue 2 (2022)

Author(s):
Snehasmita Panda, Gyanendra Kumar Gaur, Sheikh Firdous Ahmad, Swagatika Priyadarshini, Amit Kumar and Triveni Dutt

Abstract:
Many genetic analysis require knowledge of biological relatedness between samples. In large-scale genetic association studies, the estimated kinship is used to remove cryptic relatedness, control for family structure and estimate heritability for trait of interest. However, estimation of kinship is challenging using conventional methods, such as pedigree and polymorphic microsatellites data. In the present study, Porcine SNP60K genotype and pedigree data were used to explore kinship analysis of Landlly pigs. Genomic kinship analysis of 69 Landlly pigs was done using a IBD-based coefficient and by setting of different levels of minor allele frequency and linkage disequilibrium. For pedigree based analysis a total 2462 Landlly pigs data has been utilized. Pearson’s correlation coefficient was calculated between estimates of pedigree and genotyping kinship coefficients. In this study, the mean genotypic and pedigree kinship coefficient were 0.061 ± 0.01 and 0.055 ± 0.008, respectively. Moderate correlation (0.362) was observed between pedigree and genomic kinship coefficient. This investigation provided an inference that genomic kinship coefficient might be used in place of pedigree-based kinship method effectively in Landlly population.