Vol. 11, Special Issue 12 (2022)

The present clinical study was conducted to assess the sedative effect of dexmedetomidine with atropine sulphate as preanaesthetic agents on thiopentone sodium or propofol as induction and isoflurane as maintenance anaesthetic agents in dogs based on evaluation of anaesthetic, clinico-physiological and haemato-biochemical parameters. Twelve clinical cases of dogs presented for surgical interventions were randomly divided into two groups with the objective to develop a safe anaesthetic protocol. All dogs were premedicated with atropine sulphate @ 0.02 mg/kg intramuscularly and dexmedetomidine @ 5 µg/kg intravenously. Anaesthesia was induced by intravenous administration of 2.5% thiopentone sodium in group I and 1% propofol in group II till effect and maintained by isoflurane with 100% oxygen throughout the surgery. Dexmedetomidine showed potent dose sparing effects on induction dose of thiopentone sodium and propofol. Sedation quality was excellent with smooth induction and rapid recovery without any complication in both the groups. Both combinations produced adequate analgesia, muscle relaxation and sufficient anaesthetic depth to perform surgery. No significant difference was observed in the clinico-physiological and haemato-biochemical parameters in both the groups.