Vol. 11, Special Issue 12 (2022)

Author(s):
Gautam Parikh and Mrinal Kr. Nath

Abstract:
The present investigation was conducted to study the effect of Antimicrobials on haematological parameter and biochemical parameter of Escherichia coli (E. coli) affected diarrhoeic calves. A total of 153 faecal swabs were screened from various cattle farms located in and around Guwahati of which, 78 samples showed positive for E. coli. Isolates were identified based on morphological and cultural characteristics from which total of 18 E. coli affected diarrhoeic calves selected and divided into 3 groups comprising 6 animals in each i.e., T1 – Consisted of 6 animals and were treated with ciprofloxacin at the dose rate of 10 mg/kg body weight orally twice daily for 5 days. T2 – Consisted of 6 animals and were treated with norfloxacin at the dose rate of 25 mg/kg body weight orally twice daily for 5 days. T3 – Consisted of 6 animals and were treated with ofloxacin at the dose rate of 20 mg/kg body weight orally twice daily for 5 days. C – Apparently healthy control (No treatment given). About 6 ml of whole blood was collected from diarrhoea affected calves by puncturing the jugular vein. Blood was collected on 0 day (pre-treatment), 5^th day and 10^th day (post treatment). Blood was analyzed for haematological parameter viz., Haemoglobin (Hb), Packed Cell Volume (PCV), Total Erythrocyte count (TEC) and Total leuckocyte count (TLC), Biochemical parameter like Total serum protein (TSP), Glucose, Sodium (Na⁺), Potassium (K⁺) and Chloride (Cl^-). Haemato-biochemical parameter in treatment trial revealed significant increase in Hb, PCV, TEC, TLC, TSP, Cl^- and decrease in glucose and Na⁺ in diarrhoeic calves in comparison to apparently healthy control.