Comparative evaluation of clinico-physiological effect of total intravenous anaesthesia of etomidate in midazolam and dexmedetomidine premedication in dogs
Mrunali Kamble, Raju Sharda, Rukmani Dewangan, SK Tiwari, SL Ali, DK Jolhe, Mohan Singh, Poornima Gumasta, PM Sonkusale and MO Kalim
The present study was conducted to evaluate the efficacy of use of etomidate as total intravenous anesthesia in dogs. The research was conducted on 16 dogs of either sex, age group 7-12 years, presented to the TVCC and Department of Surgery & Radiology, Durg. Animals were randomly divided into two equal groups Group I and Group II consisting eight animals in each group. All the animals of both the groups premedicated with Inj. atropine sulphate @ 0.04 mg/kg intramusculary. In Group I dogs premedicated with Inj Midazolam @ 0.4 mg/ kg body weight and Group II premedicated with Dexmedetomidine @ 0.010 µg/kg body weight intravenously after 10 minutes. For induction after 10 minutes anaesthesia was induced by Inj. Etomidate @ 1.5mg/kg body weight intravenously to each animal of both the groups. Maintenance of anaesthesia for 2 hrs was achieved with repeated bolus with Injection of etomidate @ 0.5mg/kg body weight at different time intervals in both the groups. Anaesthetic combination were evaluated by clinical and physiological observations. The clinical parameters were recorded at different time interval in minutes and physiological parameters at 0, before induction, 15, 30, 45, 60, 90 and 120 minutes intervals were recorded. Induction quality was excellent, smooth and sternal recumbency and complete recovery was observed smoothly without struggling in both the groups after induction. The quality of anaesthesia was recorded on a scale 1 to 4 as shown score 1 – Poor, score 2 -Fair, score 3- Good and score 4- Excellent in both the groups. In both the groups provided satisfactory surgical plane of anaesthesia in dogs but it was excellent in Group II which was premedicated with Inj. Dexmedetomidine than Group I which was premedicated with Inj. Midazolam.
How to cite this article:
Mrunali Kamble, Raju Sharda, Rukmani Dewangan, SK Tiwari, SL Ali, DK Jolhe, Mohan Singh, Poornima Gumasta, PM Sonkusale and MO Kalim. Comparative evaluation of clinico-physiological effect of total intravenous anaesthesia of etomidate in midazolam and dexmedetomidine premedication in dogs. The Pharma Innovation Journal. 2021; 10(11S): 15-20.