Vol. 14, Issue 8 (2025)

Author(s):
Saadeya Ali Al-Gnami

Abstract:

Objective: this study designed to discovery probability for using of baicalin to decrease toxic effects of acrylamide in functions of kidney and liver in female rabbits.

Methods: twenty adult female rabbits were used, about (11-12) month old, with average weight about (1100 1600) gm. The animals were distributed into four groups (5 animals per each) and drenched orally for 30 following days. Control group (C) drenched 1 ml of distilled water. T₁ group drenched baicalin (50 mg/kg B.W). T₂ group drenched acrylamide (50 mg/kg.B.W). T₃ group drenched both baicalin and acrylamide at the same time. After the termination of the treatment, the samples of blood were taken from the heart to obtain the serum for estimation of uric acid, creatinine, ALT and AST.

Results: Our study revealed an important increased in uric acid, creatinine, ALT and AST levels at T₂ group while these parameters decreased in T₃ group.

Conclusion: Baicalin (50 mg/kg) plays a great role in reducing the side effect resulting from treatment with acrylamide in the liver and kidney functions in female rabbits.