Vol. 14, Issue 8 (2025)

The present work was aim to develop a mouth dissolving film of Ramosetron HCl using hydrophilic polymers HPMC E5, HPMC E15 and HPMC 50 cps. Mouth dissolving films were prepared by solvent casting method. Formulation batches were prepared by varying the quantity of polymers and plasticizer and evaluated for physical properties, thickness, mechanical properties, surface pH, disintegration time, and in vitro dissolution studies. Fast dissolving film are having smooth surface and they are elegant. The thickness of the fast dissolving films was found 0.18-0.21 mm. Surface pH was found 6.61-7.14. The drug was dispersed in the range of 2.36-2.57. Film of 2 x 2 cm 2 size taken and disintegration time checked visually was found 58-81 sec. In vitro Dissolution studies shows drug release in range of 90.26±0.43-99.81±0.09 in 15 min. from formulation batch F6 selected as optimized Batch for further accelerated stability studies.
There were no considerable changes in physical parameters of film such as Appearance, Disintegration time (sec) Cumulative% releases of formulation F6 after accelerated study.