Vol. 14, Issue 8 (2025)

Author(s):
OO Khaniukov and MI Yalovenko

Abstract:
This article reviews the role of interleukin-10 (IL-10) in the pathogenesis and course of Coronary Artery Disease (CAD), hypertension and chronic heart failure (CHF). IL-10 is a key anti-inflammatory cytokine that plays an important role in regulating the immune response and reducing inflammation. In the context of cardiovascular diseases (CVD), inflammation is one of the leading mechanisms of their development and progression. Studies show that IL-10 levels can be altered in patients with CAD, hypertension and CHF, which indicates its potential participation in protective or adaptive responses of the body. The mechanisms by which IL-10 may influence endothelial function, vascular and myocardial remodeling, and the course of atherosclerosis are reviewed. The prognostic value of IL-10 levels for assessing the risk of complications and severity of CVD is discussed. The tasks of the study was to determine the activity of hc-CRP and pro-inflammatory cytokines (interleukins 1?,-6 and anti-inflammatory cytokine (IL-10) in patients with coronary artery disease, Permanent Atrial Fibrillation (AF) and without AF in a population-based comparison with healthy volunteers. The study shoved, that in patients with coronary artery disease combined with hypertension and permanent AF, a more pronounced (p<0.05) activity of anti-inflammatory IL-10 by 127.9% is observed compared to patients without AF. Elevated serum levels of IL-10 > 23.0 pg/ml increase the chances of developing AF by 12.4 times in patients with coronary artery disease and hypertension, which can be used as additional criteria for diagnosing and predicting AF in this category of patients.