Vol. 14, Issue 6 (2025)

Author(s):
Priyanka Rani, Shailja, Balvinder Singh and Pawan Jalwal

Abstract:
Age-related neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases, are primarily associated with oxidative stress and free radical-induced neuronal damage. Natural compounds with potent antioxidant properties offer a promising approach for neuroprotection. Ganoderma lucidum, a well-known medicinal mushroom, contains bioactive compounds with strong pharmacological potential. This study aimed to investigate the in-vitro antioxidant activity of Ganoderma lucidum and its potential implications in mitigating oxidative stress linked to neurodegeneration. Phytochemical screening revealed the presence of flavonoids, phenolics, tannins, and triterpenoids. Antioxidant capacity was assessed using DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2?-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) radical scavenging assays. The results showed dose-dependent antioxidant activity, with significant radical scavenging potential. These findings support the potential use of Ganoderma lucidum as a natural antioxidant and lay the groundwork for further studies exploring its neuroprotective mechanisms in age-related neurodegenerative conditions.