Vol. 14, Issue 5 (2025)

Author(s):
Kamal Yaseen Ali, Safa Rida Shakkor and Ahmed Moussa Khalil

Abstract:
This study focused on the synthesis and characterization of eight novel Schiff base derivatives (A1-A8) derived from trimethoprim (TMP), a well-known antibacterial agent. The derivatives were synthesized via condensation reactions between TMP and various aldehydes in a 2:1 molar ratio, catalyzed by glacial acetic acid under reflux conditions. The synthesized compounds were characterized using Fourier Transform Infrared Spectroscopy (FT-IR), Nuclear Magnetic Resonance (¹H-NMR), and elemental analysis (CHNS). Key spectral data, such as the disappearance of NH₂ and aldehyde C=O bands in FT-IR and characteristic imine proton signals in NMR, confirmed the formation of Schiff bases. Physical properties, including melting points (65-145°C) and reaction yields (75-88%), were documented. The results demonstrated successful synthesis of structurally diverse derivatives with potential applications as antibacterial agents.