Vol. 14, Issue 5 (2025)

Author(s):
Rohan Gugaliya, Krushna Kurne, Sidhesh Nahata and Sanjay Patil

Abstract:
Hydrogels, characterized by their three-dimensional water-soluble polymer networks, exhibit remarkable biocompatibility, tunable porosity, and controlled drug delivery capabilities. These properties position hydrogels as transformative tools in cancer therapy, offering applications across chemotherapy, radiotherapy, immunotherapy, photothermal, and photodynamic treatments. Their adaptability in various forms microgels, nanogels, and injectable or implantable systems enables precise, localized drug delivery, reducing systemic toxicity while enhancing therapeutic efficacy. Recent advancements highlight their role in stimuli-responsive drug release, targeted therapies, and immune modulation within tumor microenvironments. Moreover, bio-inspired and DNA-based hydrogels show promise in optimizing cancer treatment through innovative designs that mimic natural systems or incorporate immune-enhancing properties. Although challenges like biodegradation and inflammatory responses persist, collaborative research underscores their potential in personalized medicine. This versatility of hydrogels marks them as critical elements in the evolving landscape of targeted cancer therapies, fostering precision and efficacy while addressing limitations in conventional treatments.