Vol. 14, Issue 4 (2025)

Author(s):
C Prajisha, Sebastian Renjith, R Uma, PD Divya, Palekkodan Hamza, PT Dinesh, K Naheef

Abstract:
MicroRNAs (miRNAs) are small, non-coding RNA molecules that play a crucial role in post-transcriptional gene regulation across a wide range of biological processes and cellular pathways. They are increasingly recognised as key regulators of cancer progression, influencing tumour growth, invasion, and the expression of cancer-associated genes. Among them, miR-429 has been identified as a significant player in tumorigenesis, contributing to enhanced proliferation and migration in human breast cancer. In this study, the target genes of cfa-miR-429, which was found to be up regulated in canine mammary tumour, were predicted. Gene Ontology (GO) and pathway analyses of the predicted target genes were conducted using various online bioinformatics tools. The prediction and subsequent functional enrichment analyses revealed that the target genes of cfa-miR-429 were significantly enriched in multiple cancer-related pathways, offering valuable insights into the molecular mechanisms underlying cancer development.