Vol. 14, Issue 3 (2025)

Author(s):
Showmy KS, Marymol Shajan, Abhinand KS, Abhirami VR, Jyothirmayi, Agna VS, Rithambara Haridas and Ananthakrishnan TV

Abstract:
Alanine Aminotransferase (ALT), also known as serum glutamate-pyruvate transaminase (SGPT), is a key enzyme in amino acid metabolism. It catalyzes the conversion of alanine and α-ketoglutarate into pyruvate and glutamate, playing a crucial role in gluconeogenesis, especially during fasting or low carbohydrate intake. ALT is an important biomarker for liver health, as elevated levels indicate liver damage or inflammation, though they are not specific to a single condition. Regular monitoring of ALT, alongside other liver function tests, helps assess disease severity, track progression, and evaluate treatment effectiveness. Lowering ALT levels through medications and lifestyle changes supports liver health, though it is not a cure. Ayurvedic detoxification is believed to aid liver function by eliminating toxins. Tinospora cordifolia (Guduchi) is a well-known Ayurvedic plant with potential hepatoprotective properties. In this study, 16 phytochemicals from T. cordifolia were analyzed for molecular docking interactions with ALT using PyRX software. Ecdysterone exhibited the least docking energy, suggesting strong binding with the ALT receptor. Preliminary research indicates that ecdysteroids possess anti-inflammatory and antioxidant properties, making them promising for pharmacological applications. However, further studies are required to validate their therapeutic potential.