Determination and comparison of the tablet properties of commercially marketed immediate release tablets of diclofenac sodium and paracetamol in South-South Nigeria

Iyaeneomi Ransome Daka; Joachim Omojaide Odigie; Hope Delesi Kagbo; Sunday Okorie Abali

doi:10.22271/tpi.2025.v14.i10c.26295

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E-ISSN Number: 2277-7695
P-ISSN Number: 2349-8242
CODEN Code: PIHNBQ
ZDB-Number: 2663038-2
IC Journal ID: 7725

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Vol. 14, Issue 10 (2025)

Determination and comparison of the tablet properties of commercially marketed immediate release tablets of diclofenac sodium and paracetamol in South-South Nigeria

Author(s):
Iyaeneomi Ransome Daka, Joachim Omojaide Odigie, Hope Delesi Kagbo and Sunday Okorie Abali

Abstract:
Background: Substandard tablets lead to poor outcomes in pain management. This study compared tablet properties of innovator and generic diclofenac sodium (50 mg) and paracetamol (500 mg) tablets in South-South Nigeria.

Methods: Physicochemical tests (weight uniformity, hardness, friability, disintegration, dissolution, content uniformity) followed pharmacopeial standards. Pharmacokinetic studies used single-dose crossover in 33 healthy volunteers. Plasma analyzed via UV; bioequivalence via 90% CI (80%-125%). ANOVA/t-tests (p? .05).

Results: Generics failed content (e.g., Panda 68.00%±5.60%, Emcap 47.79%±6.30% vs. Panadol 83.24%±1.80%). Innovators had superior bioavailability: Olfen Cmax 5.09±0.19 µg/L, AUC 112.00±8.20 mg·h/L vs. generics. 90% CI confirmed bioequivalence for Clofenac-Olfen, all paracetamol. Dissolution: Innovators slower (p< .05).

Conclusion: Select generics bioequivalent; enhanced quality controls recommended.

DOI:
https://doi.org/10.22271/tpi.2025.v14.i10c.26295

Pages: 150-154 | 417 Views 270 Downloads

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How to cite this article:

Iyaeneomi Ransome Daka, Joachim Omojaide Odigie, Hope Delesi Kagbo, Sunday Okorie Abali. Determination and comparison of the tablet properties of commercially marketed immediate release tablets of diclofenac sodium and paracetamol in South-South Nigeria. Pharma Innovation 2025;14(10):150-154. DOI: 10.22271/tpi.2025.v14.i10c.26295

Vol. 14, Issue 10 (2025)

Determination and comparison of the tablet properties of commercially marketed immediate release tablets of diclofenac sodium and paracetamol in South-South Nigeria

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