Subacute toxicity of an aqueous extract of Alternanthera pungens (Amaranthaceae) in wistar rats
Author(s):
N’dah Etchien Christelle Ekra, Kouehiouon Justin Anderson-Bel Djike, Ouga Stanislas Zahoui, Yomalan Kassi, Semi Anthelme Nene Bi and Flavien Traore
Abstract:
Alternanthera pungens (Amaranthaceae) is an African pharmacopoeia plant known for its antidiabetic properties. The aim of this study was to evluate the oral toxicity of the aqueous extract of the whole plant of Alternanthera pungens in Wistar rats. A qualitative phytochemical test was carried out. The toxicity tests were carried out in accordance with guidelines 407 of the Organisation for Economic Co-operation and Development (OECD). Oral administration of doses ranging of 500 to 2000 mg/kg bw of the aqueous extract of Alternanthera pungens in continuous doses for 28 days allowed a series of hematological and biochemical analyses. This aqueous extract contains sterols and polyterpenes, saponosides, alkaloids, catechic tannins, anthocyanins. The results of the toxicity test and the hematological and biochemical analyses indicate that this extract is non-toxic.This absence of toxicity by oral route would support its use in various therapies in traditional African medicine.
How to cite this article:
N’dah Etchien Christelle Ekra, Kouehiouon Justin Anderson-Bel Djike, Ouga Stanislas Zahoui, Yomalan Kassi, Semi Anthelme Nene Bi, Flavien Traore. Subacute toxicity of an aqueous extract of Alternanthera pungens (Amaranthaceae) in wistar rats. Pharma Innovation 2024;13(9):216-219.