Abstract:The current study aimed to evaluate the diuretic and anti-inflammatory activities of root extracts from
Rumex crispus L. by conducting pharmacological studies on experimental animals, (rats), at different doses.
The results of the study showed that the extracts possess diuretic effects and anti-inflammatory activity, and acute toxicity studies revealed that the extract is non-toxic.
The results of a study examining diuretic activity showed that the extract, at a dose of 25 mg/kg, has the most pronounced effect on kidney function, and works to increase diuresis in rats, which increases urine formation by 90% compared to the comparison drug Hypothiazide. The extract reduces the level of creatinine and urea, without affecting nitrogen metabolism and urine pH.
The results of a study examining anti-inflammatory activity showed that the extract caused significant inhibition of edema at a dose of 25 mg/kg, and the activity of these amounts did not exceed, but was remarkably close to, the activity of the comparison drug Orthofen.
Thus, extracts from the roots of Rumex crispus L. are of interest for further pharmacological studies as anti-inflammatory, antihypertensive and renal function stimulators.