Physiological and haemato-biochemical evaluation of skeletally immature dogs with tibial fractures stabilized by elastic plate osteosynthesis using veterinary cuttable plates with and without platelet rich plasma
Author(s):
Rajath MS, Nagaraju N, Nagaraja BN, Srinivasa Murthy KM, Manjunatha K, Balappanavar BR and Suresh L
Abstract:
The present study was conducted in 12 clinical cases of immature young dogs with tibial diaphyseal fractures which were stabilized by elastic plate osteosynthesis (EPO) with and without platelet-rich plasma (PRP). The dogs with tibial diaphyseal fractures were randomly divided into two groups: Group A (n=6), stabilized with EPO and PRP applied at the fracture site, and Group B (n=6), stabilized with EPO alone. Physiological and haemato-biochemical changes during the study period were recorded on pre operative, 1st, 3rd, 7th, 12th and 15th day and preoperative, 1st, 7th, 15th, 30th, 45th and 60th post operative days respectively. Observations were statistically analyzed using independent sample t-tests and one-way ANOVA. There were no significant changes in physiological parameters between groups. Both groups exhibited a transient increase in rectal temperature on the first post-operative day and elevated respiratory and heart rates on the third post-operative day, which normalized by the 15th day. Haematological parameters showed no significant differences within or between groups, with values remaining within normal limits. Variations in total erythrocyte and leucocyte counts, haemoglobin levels and differential leucocyte counts were observed initially during study period and returned to normal by day 60. Biochemical parameters - serum calcium and phosphorus levels showed slight, non-significant increase, likely due to osteoblastic activity at the fracture site. Alkaline phosphatase levels increased significantly on the 15th post-operative day in both groups, reflecting active bone healing, but returned to normal by day 60. No significant differences were found between groups in alanine aminotransferase or serum creatinine levels. The application of PRP in conjunction with EPO in treating tibial fractures in immature dogs resulted in insignificant changes in physiological and haematological parameters, with both groups displaying normal healing patterns.
How to cite this article:
Rajath MS, Nagaraju N, Nagaraja BN, Srinivasa Murthy KM, Manjunatha K, Balappanavar BR, Suresh L. Physiological and haemato-biochemical evaluation of skeletally immature dogs with tibial fractures stabilized by elastic plate osteosynthesis using veterinary cuttable plates with and without platelet rich plasma. Pharma Innovation 2024;13(8):18-22.