Vol. 13, Issue 11 (2024)

The study focused on Fucidin, a topical antibacterial agent used to treat bacterial infections by disrupting bacterial protein synthesis. The researchers aimed to formulate a topical gel incorporating various gel-forming polymers, including chitosan, to assess their effects on gel characteristics and wound healing.

Using Carbopol 934p as the gelling agent, the gel formulations were prepared through a soaking method. Infrared spectroscopy indicated that the formulations were physical mixtures, confirming the compatibility of Fucidin with the other components. The gels were evaluated for drug content, pH, viscosity, spread ability, and extrudability.

Results showed that the plain gel released Fucidin at a slower rate compared to other formulations, with the best performing formulation (F8) achieving a release rate of 99.56%. All gel formulations demonstrated significant wound contraction, with one formulation containing Fucidin, 1% chitosan, and 1% sodium alginate achieving a remarkable 99.4% reduction in wound area over 12 days.