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- E-ISSN Number: 2277-7695
- P-ISSN Number: 2349-8242
- CODEN Code: PIHNBQ
- ZDB-Number: 2663038-2
- IC Journal ID: 7725
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Vol. 12, Issue 4 (2023)
Protective effects of plumbagin against folic acid-induced oxidative stress in Swiss albino mice
Author(s):
Rajendar Bobbili, Gopala Reddy Alla, Usha Rani M, Lakshman Mekala, Kalyani Putty, Anilkumar Banothu, Vanitha Sree K, Venkata Rao K and Hanuman D
Rajendar Bobbili, Gopala Reddy Alla, Usha Rani M, Lakshman Mekala, Kalyani Putty, Anilkumar Banothu, Vanitha Sree K, Venkata Rao K and Hanuman D
Abstract:
An experimental study was conducted to evaluate the pharmacological activity of plumbagin against Folic acid-induced acute kidney injury/renal fibrosis. A total of 30 male Swiss albino mice were procured and acclimatized for one week before experimentation. Mice were randomly assigned to five groups of 6 animals each. Group 1 (control group) was administered normal saline. Group 2 was given Folic acid @ 250mg/kg BW IP given on 1st day of the experiment, Group 3 was kept as plumbagin per se group (10mg/kg IP). Groups 4 and 5 were kept as treatment groups with plumbagin @ 5 mg/kg BW IP and 10mg/kg IP, respectively, daily, along with folic acid on 1st day of the experiment. The experiment was conducted for a period of 14 days. On the 15th day the mice were sacrificed and kidneys were collected for the analysis of anti-oxidant parameters.
An experimental study was conducted to evaluate the pharmacological activity of plumbagin against Folic acid-induced acute kidney injury/renal fibrosis. A total of 30 male Swiss albino mice were procured and acclimatized for one week before experimentation. Mice were randomly assigned to five groups of 6 animals each. Group 1 (control group) was administered normal saline. Group 2 was given Folic acid @ 250mg/kg BW IP given on 1st day of the experiment, Group 3 was kept as plumbagin per se group (10mg/kg IP). Groups 4 and 5 were kept as treatment groups with plumbagin @ 5 mg/kg BW IP and 10mg/kg IP, respectively, daily, along with folic acid on 1st day of the experiment. The experiment was conducted for a period of 14 days. On the 15th day the mice were sacrificed and kidneys were collected for the analysis of anti-oxidant parameters.
The present study revealed a significant alteration in anti-oxidant profile (Nitrite assay, TBARS, SOD, GSH and Catalase) of mice treated with folic acid (group 2) when compared to sham (group 1) and there was a significant amelioration of alterations in all the parameters in group 4 and 5 when compared to Folic acid control group 2. The values of group 1 and 3 were comparable without any significant differences.
In conclusion, plumbagin was found to possess the ameliorating action against folic acid-induced oxidative stress. The results revealed a greater significance of amelioration in group 5 compared to group 4, as seen through restoration of anti-oxidant enzyme levels Hence, plumbagin can be used as a protective strategy for renal injury.
Pages: 2395-2397 | 307 Views 151 Downloads
How to cite this article:
Rajendar Bobbili, Gopala Reddy Alla, Usha Rani M, Lakshman Mekala, Kalyani Putty, Anilkumar Banothu, Vanitha Sree K, Venkata Rao K, Hanuman D. Protective effects of plumbagin against folic acid-induced oxidative stress in Swiss albino mice. Pharma Innovation 2023;12(4):2395-2397.
Journal code(s)
- E-ISSN Number: 2277-7695
- P-ISSN Number: 2349-8242
- CODEN Code: PIHNBQ
- ZDB-Number: 2663038-2
- IC Journal ID: 7725
Main Menu
Special Issue
Copyright Form
Identifier
The Pharma Innovation Journal
