Intravaginal Non- steroidal drug, an alternative to steroidal drug in Estrus synchronization of does
Author(s):
Sanjeev Gavimath, Narasimha Murthy, Annayappa Sahadev, Suchitra Bidare Raju, Kalmath Gavisiddappa, Shankarappa Bajanthri and Rashmi Rajashekar
Abstract:
The study was conducted with the objective of comparing the efficacy of non-steroidal and steroidal intravaginal drugs in estrus synchronization of goats. Sixteen nonpregnant does were randomly assigned into two groups of 8 each. Does of Group I was treated with locally prepared 7.5 mg letrozole sponges and Group II with intravaginal Avikesil-S sponges for 7 days and all were administered injection of 125 μg of PGF2ɑ at the time of sponge removal. Ultrasound scanning of ovaries was carried out on day 0, 3 and 7th of sponge insertion and recorded the number and size of the follicles. The goats in estrus were subjected to natural mating. Pregnancy diagnosis was carried out using B mode trans-rectal ultrasonography on 30 days post mating. No significant difference (p>0.05) in sponge retention rate and estrus response rate between the treated groups was noticed. Mean interval to estrus in Group I (87.76 ± 0.97) was significantly longer (p<0.05) than in Group II does (36.43 ± 1.23 h). The mean duration of estrus in Group I and Group II were 27.76 ± 0.96 and 25.63 ± 1.49 h respectively which did not vary significantly (p>0.05). The conception rate was similar in both the groups (71.42%). Further, pharmacokinetic studies of letrozole needed and also study involving large number of animals is required to confirm efficacy of the letrozole before it is incorporate into the estrus synchronization protocol.
How to cite this article:
Sanjeev Gavimath, Narasimha Murthy, Annayappa Sahadev, Suchitra Bidare Raju, Kalmath Gavisiddappa, Shankarappa Bajanthri, Rashmi Rajashekar. Intravaginal Non- steroidal drug, an alternative to steroidal drug in Estrus synchronization of does. Pharma Innovation 2023;12(2):3167-3170.