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Vol. 12, Issue 2 (2023)

Exposure to Fluralaner induces behavioral and reproductive alterations in Zebrafish (Danio rerio)

Author(s):
Pradnya Patil, SS Sole, Purva Joshi, Vishal P Mote, RV Gaikwad, SU Gulavane and PV Meshram
Abstract:
The newly introduced insecticide fluralaner was evaluated for its possible endocrine-disrupting ability in the zebra fish model. Dependent on pilot study results, four concentrations were selected viz., 5 mg/l, 10 mg/L., 20 mg/l, and 100 mg/1 for a 21-days exposure period. Exposed males were mated with female zebra fish. Baseline data was also generated before exposure.
Changes in the behavior were observed in dose-dependent manner, confused behavior, and colliding with the walls may be due to the antagonist effect of fluralaner on GABA receptor. A significant decrease in spawn count was observed within the groups, which might be due to deceased oviposition and possible sperm toxicity. Comparison of fecundity within the respective groups to their pre-exposure fecundity values indicated statistically significant differences due to decrease implantations. The significant rise in the mortality percent of embryos is indicative of the possibility of adverse effects of fluralaner on sperm quality. Abnormal embryo count showed a significant difference within the groups to their respective pre-exposure values. The increased level of vitellogenin biomarker in the fluralaner exposed group is indicative of disruption in the endocrine system in male zebra fish. Hence it is concluded that fluralaner shows the potential for embryo toxicity due to endocrine disruption in male zebra fish.
Pages: 2228-2238  |  444 Views  208 Downloads


The Pharma Innovation Journal
How to cite this article:
Pradnya Patil, SS Sole, Purva Joshi, Vishal P Mote, RV Gaikwad, SU Gulavane, PV Meshram. Exposure to Fluralaner induces behavioral and reproductive alterations in Zebrafish (Danio rerio). Pharma Innovation 2023;12(2):2228-2238.

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