Role of ginkgo leaf extract on cyclopentolate produced memory defects in Zebra fish for the model of Alzheimer’s disease
Author(s):
Shibanjan Paul Roy
Abstract:
In this research zebra fish induced by scopolamine was investigated by the effect of Gingko leaf extract on preventing memory impairment. I divided into 6groups of male zebra fish including the control of Cyclopentolate 0.003 ml/l to 0.006 ml/l(Cyc), Cyclopentolate plus Physostigmine 0.5 mg/kg (Physostigmine+Cyc), and Cyclopentolate plus extract at doses of 175,225,250 mg/kg (Gingko 175+Cyc, Gingko 225 mg/kg+Cyc, and Gingko 250 mg/kg), In T-maze test the spatial memory evaluated by the conditional and the measurement of fear memory done by the inhibitory avoidance test by T-maze. The results showed that the Physostigmine+Cyc group had the best time spent ratio in the T-maze by the spatial memory test, followed by Gingko 250 mg/kg+Cyc,Gingko 225mg/kg+Cyc,Gingko 175 mg/kg+Cyc, control and Cyc group, respectively, but no statistical significance. For Gingko leaf at dose of 175,225 and 250mg/kg had significantly increased latency time as 21.78±4.62, 23.78±13.04 and 18.23±18.87 min respectively. For the fear memory test of Zebra fish, when compared to the Cyc group (9.83±10.48 min).These result suggested that inhibitory avoidance test related to fear memory by the Gingko leaf extract attenuated memory impairment. I found that it is very useful for further research for the development of Gingko leaf extract as a health product to develop the symptoms of Alzheimer’ s disease.
How to cite this article:
Shibanjan Paul Roy. Role of ginkgo leaf extract on cyclopentolate produced memory defects in Zebra fish for the model of Alzheimer’s disease. Pharma Innovation 2023;12(2):1921-1924.